Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia. • Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date • Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia • Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists
1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy 2. Epidemiology of Pregnancy-Related Hypertension 3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia 4. Preconceptional and Periconceptional Pathways to Preeclampsia 5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies 6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome 7. The Immunology of Preeclampsia 8. Trophoblast Extracellular Vesicles in Preeclampsia 9. Angiogenesis and Preeclampsia 10. Vascular Endothelial Cell Dysfunction in Preeclampsia 11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy 12. Cardiometabolic Antecedents of Preeclampsia 13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia 14. The Kidney in Normal Pregnancy and Preeclampsia 15. Salt, Aldosterone, and the Renin- Angiotensin System in Pregnancy 16. Platelets, Coagulation, and the Liver 17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy 18. Prediction and Prevention of Preeclampsia 19. Long-Term Effects of Preeclampsia on Mothers and Offspring 20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets 21. Harmonization of Data and Biobanks for Preeclampsia Research
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